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Why address everyday inflammation?


Neurophysiological?


  • What exactly are you measuring?

    Well, thanks to the egg, the biosensor we have invented, and exclusive breath-controlled games, we measure your heart rate variability (HRV), your respiratory rate (RR) and... your ability to concentrate on the game.

    HRV refers to various methods of assessing neurophysiological activity on your autonomic nervous system (ANS) via beat-to-beat variation in the heart over time, in order to analyze and interpret the outflow of your ANS.

    Simply put, a higher HRV is indicative of higher parasympathetic nervous system outflow via the vagus nerve, and means, less inflammation. With respect to your RR and concentration, these are used to put your data in context, and finely, dynamically decipher your metaflammation.

  • Can heart rate variability assess my inflammation?

    Your metaflammation is low-grade: it requires high sensitivity blood tests to be measured, and cannot, therefore, be repeated often enough to catch subtle changes when they occur. The high accuracy measurement of your hreat rate variability (HRV), properly protocoled, and interpreted with the right analytical norms and metrics is a remarkable method to assess your inflammation the noninvasive, easy-to-repeat way. Our analytical processes are correlated with high sensitivity blood biomarkers of inflammation. Oh, and you can repeat as much as you wish: no needle, no appointment, just fun gameplay :)


Slow breathing?


  • A very ancient practice.

    Meditation and yoga are popular. Science shows that their beneficial pysiological and mental benefits are largely associated with controlled, regulated, guided breathing they have in common, and the effect such respiratory practice has on your autonomic nervous system (ANS), mainly by stimulating the parasympathetic nervous system (PNS) for better balance and immune response.

  • How to:

    Breathing exercises are a simple practice that involves minimizing external distractions and paying closer attention to your breathing.

    There are numerous types of breathing exercises, each with slight variations in terms of how it’s practiced, all bringing your focus to the present moment. 

    We combine deep breathing and purse lip breathing. Deep breathing exercises involve taking a deep breath, holding it for a few seconds, and then releasing it slowly. Pursed lip breathing involves inhaling through your nostrils and exhaling slowly through pursed lips.

    Our games guide you toward the breathing frequency of 0.1Hz, or about 6 breath per minute, a powerful technique.

    That breathing exercises help improve mood, reduce stress, promote sleep, you already know. 

    In addition, in recent years, you probably often stumbled across articles about studies and promising research that link breathing exercises with weight loss and boost fat burning. In addition, reducing stress is known to decrease food cravings and slow breathing supports hunger control

  • Activating the vagus nerve...

    Neurophysiology explains how controlled breathing stimulates your vagus nerve. When you play our games, you practice respiratory vagal nerve stimulation (rVNS). Essentially, you are hacking the brain / body connection to enhance anti-inflammatory response and therefore further support your efforts to get and stay healthy. At the same time, you allow a dynamic assessment of your inflammation, where we measure both your inflammatory status "at rest" and upon stimulation. You may think of it as similar to the Bruce Test, used to evaluate your heart. Using a protocol allows to baseline your data and to contextualize its measurement. 

    HRV is directly influenced by your breathing rate, because of the change in heart period corresponding with inspiratory and expiratory phases, a phenomenon called respiratory sinus arrhythmia (RSA). 

  • Plasticity?

    Neural plasticity, also known as neuroplasticity is the ability of the nervous system to change its activity, structure, functions, in response to stimuli such as deep, slow breathing. This study investigates the effects of breathing practice from a neuroplasticity angle, resulting in increased wellbeing and productivity. Research shows that breathing exerciese can have a direct effect on the overall activity level of the brain. Furthermore, since breath-controlling a game is an activity that is new and challenging to you, getting better at it will further your neuroplastic progress. Two consecutive heartbeats are influenced by hundreds of different factors and neural inputs resulting from the communication of organ demands to the brain, and back, through neurotransmitters. HRV reflects the capacity of your brain and body to adapt to daily challenges.


Metaflammation


  • I thought inflammation protected me.

    Acute inflammation does protect you against physical injury, virus, bacteria, chemical pollution... COVID-19, and is critical to survival.

    But recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation that lingers in your body, fluctuating at low levels and yet making you less productive, and paving the way for disease.

  • About weight and inflammation.

    Weight gain and increased inflammation are related, and scientific studies show that weight loss reduces inflammation. However, you can be overweight and metabolically healthy, and "normal-weight," or even "skinny fat," with unhealthy inflammation. Assesing lifestyle, or metabolic inflammation, a.k.a. "metaflammation" changes over time reflects the ability, the "reserve," your brain and body have to keep you healthy.

  • Never heard of metaflammation?

    This diagram will help you figure out in no time. Research focuses on causes by groups, or explain metaflammation as an evolutionary mismatch. Being metabolically healthy means not only that you don’t have metabolic disorders - heart disease, diabetes, cancer, but also that you don’t have earliest signs of these diseases. Low metaflammation means that you maintain a proper regulation and management of your diet, energy, stress, sleep, essential for health

    Science has established that modern lifestyle, physical inactivity, poor diet, lack of sleep, negative events, overcommitment, effort-reward imbalance, emotional problems can all increase levels of inflammation in your brain and body. From the teen years through the 40s, such social, environmental, everyday factors cause low-grade, silent, persistent inflammation also called "metaflammation," that lowers well-being and performance, and leads to metabolic, mental, chronic diseases.

  • Stress-related diseases?

    Scientific evidence connects 75%–90% of human diseases to cumulative stress. Research couldn't yet clearly understand how stress contributes to disease, but everyday, low-grade  inflammation is the common ground to all stress-related diseases.


(Over) Weight


  • Isn't BMI good enough?

    BMI is not a measure of health. A BMI over 25 does not mean that you are unhealthy or will become so. A BMI between 18.5 and 24.9 doesn't translate into healthy either. BMI makes no difference between body fat and lean muscle, or between subcutaneous fat (under the skin), visceral fat (around abdominal organs) carries more risk, and fat deposits in the liver and muscles. Its calculation tends to tell tall people that they are fatter than they really are. Metabolic inflammation is a better individual assessment of "health vs. weight."

  • About my genetics?

    Genetics probably plays a role in excess weight, but research shows that your health is mostly determined by non-heritable factors, through reaction and adaptation to your everyday life. Your health depends mostly on everyday behaviors and a measure of the way those affect your inflammatory response helps you identify your own pro-inflammatory behaviors.

  • Fatphobia and the "perfect body."

    This is our responsibility as a society to destigmatize weight. Weight bias and all negative ideologies associated with weight have generated endless cycles of diet fads, eating and mental disorders. The focus must now be on health, not on weight, and checking your inflammation over time and related to triggers is central to refocusing our relationship to our bodies.

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